http://www.turnereye.com/blog/lasik-eye-surgery-news/what-is-flomax.html Lasik Eye Surgery San Francisco California Wed, 03 Dec 2008 22:25:42 +0000 http://wordpress.org/?v=2.0.1 http://www.turnereye.com/blog/lasik-eye-surgery-news/what-is-flomax.html#comment-44 Thu, 15 Jun 2006 23:34:14 +0000 http://www.turnereye.com/blog/lasik-eye-surgery-news/what-is-flomax.html#comment-44 [...] As quoted from the EyeWorld article, “we found overwhelming evidence that IFIS is associated with the use of tamsulosin (Flomax®), a systemic alpha-1 antagonist medication. This drug relaxes the smooth muscle in the bladder neck and prostate, improving urinary flow in patients with symptomatic benign prostatic hypertrophy (BPH). Flomax is highly selective for the alpha-1A receptor subtype that predominates in the prostate. It is therefore more uroselective compared to other alpha-1 blockers for BPH, such as Hytrin and Cardura. For this reason, it is currently the most commonly prescribed medication for BPH. Interestingly, we did not find that Hytrin or Cardura caused IFIS.” The studies say their review of the pharmacologic literature suggests that the same alpha-1A receptor subtype is also present in the iris dilator smooth muscle. “We postulate that prolonged pharmacologic blockade results in loss of normal iris dilator smooth muscle tone. This deficient tone produces the floppy iris behavior caused by normal intraocular fluid currents during surgery,” wrote the authors. The authors described the clinical features of IFIS, based upon more than 30 cases that are reported in their paper. In addition to subnormal preoperative pupil dilation, IFIS is characterized by repeated incisional prolapse of a billowing, floppy iris, causing progressive intraoperative miosis that is not prevented by sphincterotomies and mechanical pupil stretching. Their retrospective study documented a higher rate of posterior capsule rupture. [...] […] As quoted from the EyeWorld article, “we found overwhelming evidence that IFIS is associated with the use of tamsulosin (Flomax®), a systemic alpha-1 antagonist medication. This drug relaxes the smooth muscle in the bladder neck and prostate, improving urinary flow in patients with symptomatic benign prostatic hypertrophy (BPH). Flomax is highly selective for the alpha-1A receptor subtype that predominates in the prostate. It is therefore more uroselective compared to other alpha-1 blockers for BPH, such as Hytrin and Cardura. For this reason, it is currently the most commonly prescribed medication for BPH. Interestingly, we did not find that Hytrin or Cardura caused IFIS.” The studies say their review of the pharmacologic literature suggests that the same alpha-1A receptor subtype is also present in the iris dilator smooth muscle. “We postulate that prolonged pharmacologic blockade results in loss of normal iris dilator smooth muscle tone. This deficient tone produces the floppy iris behavior caused by normal intraocular fluid currents during surgery,” wrote the authors. The authors described the clinical features of IFIS, based upon more than 30 cases that are reported in their paper. In addition to subnormal preoperative pupil dilation, IFIS is characterized by repeated incisional prolapse of a billowing, floppy iris, causing progressive intraoperative miosis that is not prevented by sphincterotomies and mechanical pupil stretching. Their retrospective study documented a higher rate of posterior capsule rupture. […]

]]> http://www.turnereye.com/blog/lasik-eye-surgery-news/what-is-flomax.html#comment-41 Wed, 14 Jun 2006 22:52:54 +0000 http://www.turnereye.com/blog/lasik-eye-surgery-news/what-is-flomax.html#comment-41 [...] « Effects of Flomax [...] […] « Effects of Flomax […]

]]> http://www.turnereye.com/blog/lasik-eye-surgery-news/what-is-flomax.html#comment-40 Wed, 14 Jun 2006 20:50:44 +0000 http://www.turnereye.com/blog/lasik-eye-surgery-news/what-is-flomax.html#comment-40 [...] « An Eye for an Eye Effects of Flomax » [...] […] « An Eye for an Eye Effects of Flomax » […]

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